BDBM286984 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one::US10294223, Cpd No. 6::US11078199, Cpd 6::US9567334, Example 6::US9815834, Compound 6

SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1

InChI Key InChIKey=PUIXMSRTTHLNKI-UHFFFAOYSA-N

Data  4 KI  21 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 286984   

TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Affinity DataKi:  73nMAssay Description:Irreversible inhibition of human FGFR4 preincubated with enzyme followed by peptide substrate addition by caliper capillary electrophoresis methodMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human FGFR4 preincubated for 15 mins followed by peptide substrate addition measured after 3 hrs by caliper capillary electrophoresis m...More data for this Ligand-Target Pair